Get involved in the open Expression of Interest (EOI) call for researchers from the early phase (ECMC) and late phase (NIHR) cancer networks

We are delighted to announce our current Expressions of Interest (EOI) call is open

The ECMC Combinations Alliance and the NIHR CRN Industry Alliance are collaborating to support access to multiple molecules from several of our partners. We invite researchers, from both the ECMC and NIHR networks, to submit novel proposals involving one or more of the novel agents tabled below in combination with standard of care chemotherapy, and/or radiotherapy, and/or another novel drug.

The molecules, key dates for webinars, EOI submission and the triage process are also detailed below. We encourage early engagement with key collaborators, including contact with the partner molecule specialist, to support your proposed combination. The Combinations Alliance team can assist early phase combinations throughout the process having moved from CRUK's Centre for Drug Development into the ECMC Programme Office. NIHR can assist throughout with late phase combination proposals.

Closing date 30 November 2017

Data packs are linked to the respective agents below. In addition, summary sheets are attached to 'AstraZeneca'. Please email the primary contact(s) for each drug as necessary.

Question and Answer Session

The minutes taken during the 3rd Nov webinar summarising the questions and answers regarding the agents above can be downloaded by clicking here.

The process flow

1. Open call
2. Webinar
3. Close call
4. Triage #1
5. Triage #2
6. CRC submission
7. CRC meeting
8. Trial open
9. Delivery 

How to get involved

• Review the drugs on offer and consider a novel proposal with either another novel drug, chemotherapy or radiotherapy
• Contact us to attend the webinar(s) relevant to the drug(s) of interest to find out about the latest data and opportunities
• Complete and submit the non-confidential EOI form to CombinationsAlliance@cancer.org.uk by 30 Nov
• Triage 1 - EOI feedback provided by early Dec with EOIs of interest progressing to Triage 2 (Workshop- Feb 2018)
• EOIs of interest confirmed post workshop will be invited to submit to CRUK’s Clinical Research Committee (CRC)
• Trial open expectation is within 12 months of CRC meeting.
• Contact us should you require any additional information 

Key dates

• EOI submission deadline: 30 November, 2017
• EOI Feedback: early December 2017
• F2F workshop for invited applicants:  February 2018
• Workshop feedback: mid February 2018
• CRC submission deadline: May 2018
• CRC meeting: November 2018
• Trial open: November 2019